UTIs · Cystitis

A UTI answer at 2am that knows which antibiotic actually worked last time.

Clara reads your symptoms against your full chart in seconds, spots red flags like pyelonephritis, and routes you to in-person care when warranted.

Get started How it works
Burning when I pee, started last night. No fever, no back pain. Feels like last year's UTI.
Clara
Your last UTI cultured E. coli sensitive to nitrofurantoin, and no fever or flank pain makes pyelonephritis unlikely. Nitrofurantoin 100 mg twice daily for 5 days is a reasonable first-line here. I'll send this to our doctor to sign off.
If fever or flank pain shows up, what should I do?
How it works

Substantive clinical reasoning first. Clinical sign-off. Honest triage when in-person is safer.

1

Tell Clara what's going on

Describe symptoms, timing, fever or flank pain, pregnancy status, and whether this has happened before. Clara auto-pulls your prior cultures, current medications, and allergies from 150,000+ connected records.

2

Chart-aware AI triage

Clara's AI checks your symptom pattern against IDSA guidelines for uncomplicated cystitis, cross-references your last culture's sensitivity profile, and screens for pyelonephritis red flags, pregnancy, and recent antibiotic exposure.

3

Clinical sign-off or honest handoff

For uncomplicated lower UTIs in adult non-pregnant women, a licensed physician reviews Clara's plan and signs off on a first-line antibiotic. For red flags (fever, flank pain, pregnancy, male UTI, recurrent pattern), Clara routes you to in-person urgent care or primary care.

Burning at 2am. An answer before urgent care opens.

Get started Free to connect your records and start the conversation.
Treatments

First-line antibiotics, chosen against your history.

Rx · First-line

Nitrofurantoin 100 mg

Twice daily for 5 days for uncomplicated cystitis. IDSA lists nitrofurantoin as a first-line agent because of narrow spectrum, low collateral damage to gut flora, and persistently low E. coli resistance1. Not used for pyelonephritis. Not used at CrCl < 30 mL/min.

5 days
Standard course for uncomplicated lower UTI
Rx · First-line

Trimethoprim–sulfamethoxazole (Bactrim)

160/800 mg twice daily for 3 days. IDSA first-line when local E. coli resistance is below 20% and the patient hasn't used TMP-SMX in the last 3 months1. Clara checks your chart for recent courses and sulfa allergy before recommending it.

3 days
Standard Bactrim course for cystitis
Rx · Alternative

Fosfomycin 3 g single dose

One-dose option when nitrofurantoin and TMP-SMX aren't ideal (sulfa allergy, prior TMP-SMX resistance, CrCl concerns). Slightly lower eradication than nitrofurantoin or Bactrim, but the simplicity is sometimes worth it.

1 dose
Single-dose regimen
Supportive · Symptom relief

Phenazopyridine (AZO)

Over-the-counter urinary analgesic for burning and urgency while the antibiotic starts working. Does not treat the infection. Colors urine orange and is limited to 2 days alongside antibiotic therapy.

OTC
Adjunct while antibiotics take effect
Rx · Recurrent UTI

Plan for recurrent UTIs

Three or more UTIs per year is recurrent. Options include post-coital single-dose prophylaxis, low-dose daily prophylaxis, or vaginal estrogen in postmenopausal patients. Clara pulls your full UTI history and flags the pattern for clinical review.

Rx
Reviewed prevention plan
Supportive · In-person referral

When Clara sends you in

Fever, flank pain, nausea/vomiting, pregnancy, male UTI, immunocompromise, suspected STI, or recurrent failures on appropriate antibiotics all warrant in-person evaluation and a urine culture. Clara routes you to urgent care or primary care rather than prescribing.

Refer
Clara won't treat what shouldn't be treated online
Why Clara

A UTI visit that reads your chart before recommending an antibiotic.

Clara Wisp Lemonaid CVS MinuteClinic Virtual Your doctor
AI response time✓ Instant, 24/7Same-day asyncUp to 24 hoursScheduled, often minutesDays–weeks
Reads your chart & prior culturesLimitedIf your PCP
Cross-checks your med list & allergies✓ AutomatedIntake formIntake formVerbal intakeVerbal intake
CostFree to start; $25/mo membership for Rx & labs$65 per UTI course (cash-pay, medication bundled)Per-visit, cash-pay$107–$164 out of pocket per visit$150+ copay
Prescription may be covered by your insurance Sent to your pharmacyMedication is cash-pay through WispMedication is cash-pay Sent to your pharmacy
Full primary care access One membershipSingle-categoryMostly single-condition visitsPer-visit only
Honest in-person triage✓ Built inLimitedLimited

Treat this UTI. Spot the pattern across all the others.

Get started Clara remembers every culture, every antibiotic, every episode.

A UTI visit is 90% "did I pick the right antibiotic for this patient's history?".

The clinical question is not whether to treat. It's which drug, at which dose, for how long, given the patient's allergies, prior cultures, current prescriptions, and kidney function. That's a data problem, not a scheduling problem.

Chart-aware antibiotic choice

Clara reads your last culture's E. coli sensitivity profile, the last time you were on TMP-SMX, and whether nitrofurantoin is safe at your renal function. Your old doctor probably saw your last culture once at your annual visit; Clara pulls it every time.

Instant answer with real reasoning

2am symptoms don't need an async message you'll read at 11am. Clara answers now with substantive clinical content, and our doctor signs off before anything is called in.

Honest triage you can trust

A fever of 101 with back pain is pyelonephritis until proven otherwise. Clara won't prescribe for what belongs in an urgent-care exam room; it routes you there and follows up after.

A UTI answer that knows which antibiotic actually worked last time.

Get started HIPAA compliant. Records never sold or used to train public models.
Common questions

UTI questions patients ask.

What does Clara cost?
It's free to connect your medical records and start chatting with Clara. If you want Clara to provide medical advice, prescribe medications, or order labs, plans start at $25/month. All plans are HSA/FSA eligible. The cost of medications and lab work is separate and may be covered by your insurance.
How is Clara different from Wisp or my regular doctor?
Wisp will prescribe a UTI antibiotic quickly, but its visit doesn't read your chart or your prior urine cultures, and its $65 course is medication bundled cash-pay through Wisp. Your regular doctor can read your chart, but probably can't see you at 2am on a Sunday. Clara combines both: instant AI reasoning against your full chart (including your last culture's sensitivity profile), our doctor signs off, and the prescription goes to your pharmacy where it may be covered by your insurance. Can your old doctor read your entire chart and your last three urine cultures every time you message them? Clara can. And if the symptoms suggest pyelonephritis or something else, Clara sends you in. It doesn't pretend every UTI-like symptom is a UTI.
When should I go in person instead of using Clara?
Fever above 100.4°F, flank or back pain, nausea or vomiting, pregnancy, blood in the urine that's not improving, a UTI in a man, immunocompromise, or a UTI that didn't respond to a recent antibiotic course all need in-person evaluation. Clara's AI is explicitly trained to flag these and route you to urgent care or your primary-care office. If there is any concern for a kidney infection (pyelonephritis) or sepsis, the safe answer is always in-person care, not a prescription over the phone. Clara also coordinates with our AI primary care practice for ongoing follow-up once the infection is treated.
Can Clara actually prescribe antibiotics for a UTI without a culture?
Yes, for uncomplicated lower UTIs in non-pregnant adult women, empiric treatment without a urine culture is standard of care per IDSA guidelines1. Clara uses your symptoms, your prior culture history, local resistance patterns, and your medication list to pick an appropriate first-line antibiotic; our doctor signs off before anything is called in. For complicated UTI, pyelonephritis, pregnancy, or male UTI, a culture and in-person evaluation are appropriate.
I get UTIs all the time. Can Clara help me stop them?
Three or more UTIs in a year is recurrent UTI. Clara pulls your complete UTI history across connected records, checks whether your recurrences have been the same organism, and walks through prevention options with you: post-coital single-dose prophylaxis, low-dose daily prophylaxis, vaginal estrogen for postmenopausal patients, and behavioral adjustments. Our doctor signs off on any prescription plan. If the pattern suggests something more than classic recurrent cystitis, Clara routes to a urology referral.
Does cranberry or D-mannose actually work?
For acute UTI treatment, no. Cranberry and D-mannose are not treatments and won't clear an active infection. For prevention, the evidence is mixed but generally favorable for cranberry products in reducing recurrence in women prone to UTIs2. D-mannose has less rigorous evidence. Neither is a substitute for antibiotics during a symptomatic infection.
Is Clara a real medical practice?
Yes. Clara is licensed in all 50 states. Every prescription, lab order, and diagnosis is reviewed and signed off by a licensed physician. Clara's AI handles intake, clinical reasoning, triage, and follow-up; our clinicians provide the medical oversight required by state law.
What is my data used for?
Clara is HIPAA compliant. Your records are used to personalize your care and are never sold or used to train public AI models.
Can I use Clara for other health issues too?
Yes. Clara is full-service AI-first primary care. One membership covers UTIs alongside acid reflux, allergies, respiratory infections, chronic conditions, labs, preventive care, and everything else.

An AI that reads your chart before prescribing.

Connect your records for free. See what a UTI visit looks like when the AI already knows your prior cultures, your allergies, and which antibiotics have worked before.

Get started