Losartan · ARB

Care that knows when losartan is the right move, not just a refill.

Losartan is the ARB of choice when an ACE inhibitor is intolerable. Clara auto-syncs your chart and drafts the plan against every medication, allergy, and lab on record.

Get started How it works

I've been on lisinopril 10 mg for 6 weeks. The dry cough keeps me up. What now?

Clara

ACE cough is a class effect, and your home BP is 134/86 on lisinopril (the drug works; we just need to swap to an ARB). I'd switch to losartan 50 mg daily. Sending to our physician.

Clara

Follow-up BMP drafted at 2 to 4 weeks. I'll track whether the cough resolves and flag if potassium trends up.

How it works

Losartan chosen from your data, not a template.

Connect your chart

Clara auto-syncs your records from 150,000+ doctors' offices, hospitals, clinics, labs, and wearable devices. Past ACE trials, proteinuria, echo reports showing LVH — it's all pulled in. Free.

Clara reasons across your full context

Clara reads your lab history (potassium, creatinine, urinary albumin), your medication list, and your BP trend, then drafts a starting dose of losartan (typically 50 mg once daily) plus baseline and follow-up labs. A licensed physician reviews and signs off.

Watch for response, not just refills

Clara watches your home BP trend and follow-up BMP, flags potassium drift, and drafts a dose step-up to 100 mg or an add-on agent against your full chart if you're not at goal.

How Clara uses losartan

Starting doses, the three on-label indications, and common combinations.

Rx · Hypertension

Losartan 50 mg daily

Usual starting dose for adult hypertension, up to 100 mg daily. Lower starting dose (25 mg) when a patient is volume-depleted or on a diuretic¹.

25–100 mg

Usual daily range, once or twice daily¹

Rx · Stroke risk reduction

Hypertension + LVH

In the LIFE trial (9,193 patients with hypertension and left ventricular hypertrophy), losartan reduced the primary composite of CV death, MI, and stroke by 13% vs. atenolol².

13%

Relative reduction in LIFE primary composite²

Rx · Diabetic nephropathy

Type 2 diabetes with proteinuria

Indicated to delay progression of diabetic nephropathy in type 2 diabetes with a history of hypertension¹. RENAAL showed a 16% reduction in the composite of doubling of creatinine, ESRD, or death³.

16%

Relative reduction in RENAAL primary endpoint³

Rx · Combination

Losartan + HCTZ

Common pairing when monotherapy does not reach goal. Adding low-dose hydrochlorothiazide provides additive BP lowering and offsets ARB-associated potassium elevation.

Maximum labeled dose

Baseline · Labs

Basic metabolic panel

Baseline before starting an ARB, then at 2 to 4 weeks and after dose changes. Clara drafts the order as part of the plan. Ad-hoc lab orders at Labcorp or Quest may be covered by your insurance.

K + Cr

Tracked at every change

Supportive · Lifestyle

Sodium, DASH, weight

Clara layers DASH-style eating, reduced sodium, and weight trend against your home BP readings and wearable resting heart rate, for additive BP lowering on top of the ARB.

Tracked

Integrated with wearables and home cuff

Why Clara

An ARB is not interchangeable with an ACE inhibitor. The AI should know the difference.

	Clara	GoodRx Care	Circle Medical	Your doctor
24/7 AI clinical chat with full-chart reasoning	✓ Unlimited	Per-visit only	Visit-based	✗
Automated switch from ACE to ARB on reported cough	✓ Drafted instantly	New visit required	New visit	Next appointment
Cost to start	Free (connect records + chat)	$49 per hypertension refill visit	$179 first visit self-pay	$150+ copay
Paid plans	$25/mo membership, HSA/FSA eligible	No membership, $49/visit ($19 w/ GoodRx Gold)	No membership, $120 follow-up self-pay	Per-visit copay
Prescription fills	FDA-approved generic, may be covered by your insurance	Sent to your pharmacy	Sent to your pharmacy	Sent to your pharmacy
Follow-up BMP (K, Cr) included	✓ Drafted automatically	Separate visit	Ordered at visit	Copay applies
Full primary care in one membership	✓	Single-visit refill	✓	✓

The AI difference

Clara reads every trial that applies to your chart.

Can your old doctor recite the LIFE-trial hazard ratio, the RENAAL endpoint, and the exact losartan dosing algorithm next to your echo report and your most recent eGFR in 15 minutes? Clara can, every time.

Cross-references your chart against the literature

If your chart shows LVH on echo or microalbuminuria with type 2 diabetes, Clara flags that losartan is on-label for stroke-risk reduction and diabetic nephropathy and pulls the supporting trial directly into the reasoning.

ACE-to-ARB switch, without a new visit

Dry cough on an ACE inhibitor does not need to wait for your next appointment. Clara drafts the switch in seconds with your potassium, creatinine, and BP trend in hand.

Potassium, watched continuously

ARBs raise potassium. Clara auto-reads your next BMP and flags any creep toward 5.5 mmol/L, catches NSAID or potassium-sparing-diuretic additions, and drafts a plan before you feel it.

Common questions

Losartan questions patients ask.

How is Clara different from a single refill visit?

A refill visit hands you a script and sends you home. Clara keeps reading — your home BP trend, your next BMP, your wearable data, and every other condition on your chart. If you develop potassium drift on a follow-up lab or a new medication introduces an interaction, Clara flags it and drafts a response against your full record. That is a category of continuous reasoning a one-off visit cannot do.

When is losartan the right choice instead of lisinopril?

Three common situations: (1) an ACE inhibitor caused a dry cough or angioedema; (2) there is type 2 diabetes with microalbuminuria or diabetic nephropathy; (3) hypertension with left ventricular hypertrophy, where losartan reduces stroke risk². Clara reads all three signals from your chart and drafts accordingly.

Is 50 mg the right starting dose?

For most adults with hypertension, yes, with titration to 100 mg daily as needed. Patients who are volume-depleted or on a diuretic typically start at 25 mg to avoid symptomatic hypotension¹. Clara reads those signals from your chart and drafts accordingly.

Does losartan cause a cough?

Dry cough is far less common on ARBs than on ACE inhibitors. The mechanism involves bradykinin accumulation, which ARBs do not cause — that's why the standard move when ACE cough develops is to switch to an ARB like losartan⁴.

Can I take losartan while pregnant?

No. ARBs, including losartan, carry a boxed warning for fetal toxicity — discontinue as soon as pregnancy is detected¹. If you are pregnant, planning, or breastfeeding, Clara flags this from your chart and drafts an alternative regimen.

Is Clara a real medical practice?

Yes. Clara is licensed in all 50 states and operates through affiliated professional corporations. A licensed physician reviews and signs off on every diagnosis, prescription, and lab order Clara's AI drafts. Clara's AI handles intake, monitoring, and follow-up; physicians provide medical oversight.

What does Clara cost, and can I use insurance?

Connecting records and chatting with Clara is free. Paid plans start at $25/month for medical advice, prescriptions, and lab orders. All plans are HSA/FSA eligible. Clara's membership is cash-pay and not billed through insurance. Prescriptions Clara writes go to your pharmacy and may be covered by your insurance, and ad-hoc lab orders may be covered by your insurance, depending on your plan.

Can I use Clara for other health issues too?

Yes. One membership covers full primary care. Patients on an ARB are often also managing type 2 diabetes or high cholesterol; Clara's AI connects the dots across all of them and runs preventive care on a clock.