Levothyroxine Online · AI Thyroid Care & Rx

How it works

Dose drafted from your full chart, reviewed and signed off, then Clara tracks TSH on-clock.

Connect your records

Clara auto-syncs your records from 150,000+ doctors' offices, hospitals, labs, and pharmacies. Before anything is prescribed, the AI reads every TSH and Free T4 you've had drawn, any TPO or TgAb antibody results, your weight, your resting heart rate from wearables, and every interacting medication on your chart. Free, no credit card.

A dose drafted from your full chart

Clara sizes a starting or adjusted dose by weight per the Synthroid label (approximately 1.6 mcg/kg/day for full replacement¹), checks for contraindications (uncorrected adrenal insufficiency, pregnancy considerations, cardiac disease), and runs the interaction matrix against everything on your chart. A licensed physician reviews and signs off.

Dose titrated with data

Repeat TSH at 6 to 8 weeks per the label¹ — not "at your next annual". Clara tracks symptoms, weight trend, and resting heart rate from your wearable between draws and flags under- or over-replacement early. Ad-hoc labs may be covered by your insurance; on Standard and Concierge, a bundled biomarker panel is included in the membership.

Dosing

On-label dosing that reflects your weight, comorbidity, and what else is on your chart.

Rx · Initial replacement

Weight-based full replacement

For otherwise-healthy adults with overt hypothyroidism, the Synthroid label directs full replacement at approximately 1.6 mcg/kg/day, adjusted by TSH¹. Clara applies your current weight, your baseline TSH, and any cardiovascular context before drafting.

1.6 mcg/kg

Full-replacement daily dose, Synthroid label Section 2.1¹

Rx · Older adults & CVD

Start low, titrate on labs

Older patients and patients with ischemic heart disease start at 12.5 to 25 mcg/day and titrate upward in 12.5 to 25 mcg increments every 6 to 8 weeks to avoid precipitating angina or arrhythmia¹. Clara reads your cardiac history off the chart before drafting.

25 mcg

Typical starting dose in older adults / CVD¹

Rx · Pregnancy

Dose increase in early pregnancy

Levothyroxine requirements increase meaningfully in the first trimester; many patients need a 20 to 30 percent dose increase as soon as pregnancy is confirmed, with monthly TSH monitoring during pregnancy per the label¹. Clara flags a positive pregnancy test against your current dose immediately.

+20–30%

Typical first-trimester dose increase¹

Rx · Interactions

Absorption & interacting drugs

Calcium, iron, PPIs, estrogens, bile acid sequestrants, rifampin, SSRIs, soy, coffee. Clara runs the full interaction matrix against your active med list and supplements before adjusting a dose. Take levothyroxine on an empty stomach, 30 to 60 minutes before food or other drugs, per the label¹.

Checked

In seconds, against your whole chart

Why Clara

Levothyroxine prescribing handled by an AI reading your whole chart.

	Clara	Paloma Health	Your doctor
24/7 AI clinical chat	✓ Unlimited	Async messaging with care team	✗
Reads every prior TSH, antibody, and wearable datapoint	✓ Auto-synced from 150,000+ sources	Self-uploaded records only	Only within a single practice
Cost to start	Free (records + chat)	$240/year membership ($20/mo annualized)	$150+ copay per visit
Monthly cost	From $25/mo cash-pay membership (HSA/FSA eligible)	$20/mo membership + $60/visit self-pay (or copay with in-network insurance)	Per-visit copay
Prescription may be covered by your insurance	✓ FDA-approved branded or generic	✓ (at your pharmacy)	✓
Scope of care	Full primary care (thyroid, BP, cholesterol, diabetes, menopause, mental health, longevity)	Thyroid only	Full primary care
Interaction matrix run against whole chart	✓ Automatic, every adjustment	Per-visit clinician memory	Per-visit clinician memory

The AI difference

Levothyroxine is the single drug most likely to be wrong, because nobody holds the context.

TSH drifts. Patients start new medications that block absorption. Pregnancies happen. Weights change. Hashimoto's slowly wears the gland down. The dose decision depends on all of that, all at once. A 15-minute visit cannot read it. An AI can.

Reads every TSH you've ever had drawn

Clara cross-correlates every TSH, Free T4, antibody, weight, and wearable reading in one pass and surfaces the trajectory, not the single value. Pattern-finding across thousands of datapoints is a category of work a clinician cannot do in a 15-minute visit, no matter how experienced they are.

Runs the interaction matrix in seconds

Calcium, iron, PPIs, estrogens, SSRIs, rifampin, bile acid sequestrants, soy, coffee. Clara checks the whole list against your chart before every dose change. A clinic cannot realistically do this across the full label at every visit.

Titrates on schedule, not at your annual

After a dose change, the Synthroid label asks for a repeat TSH in about 4 to 6 weeks¹. Clara places the order on schedule. The old model, where the dose quietly drifts for a year because nobody put a repeat TSH on the calendar, isn't our model.

Common questions

Levothyroxine questions patients actually search for.

Can I get a levothyroxine prescription through Clara?

Yes, where clinically appropriate. Clara's AI reads your records, drafts a dose sized to your weight and TSH, and runs the interaction matrix against your full med list. Prescriptions are called into the pharmacy of your choice and may be covered by your insurance.

What does Clara cost?

It's free to connect your medical records and start chatting with Clara. If you want Clara to provide medical advice, prescribe medications, or order labs, plans start at $25/month. All plans are HSA/FSA eligible. The cost of levothyroxine and ad-hoc lab work is separate and may be covered by your insurance. On Standard ($50/month) or Concierge ($150/month), a bundled biomarker panel (74 or 108 tests, including TSH and Free T4) is included in the membership itself.

How is Clara different from Paloma Health?

Paloma is thyroid-only. It cannot manage your BP, cholesterol, diabetes, or menopause in the same chart, and its model unbundles the $240/year membership from the $60 self-pay visit fee and from medication. Clara is full primary care — thyroid is one of many conditions the AI handles. Our $25 to $150 membership covers unlimited AI chat, prescriptions, and lab orders in one plan.

How is this different from my regular doctor?

Can your old doctor read every TSH you've had drawn in the last decade, every wearable-recorded resting heart rate, every PPI and calcium prescription, and every ferritin value every time you meet with them? Clara can. A 15-minute visit will scan the last panel; Clara cross-correlates the whole picture in one pass.

How do I take levothyroxine correctly?

Take it on an empty stomach, at least 30 to 60 minutes before food, coffee, or other medications, with a full glass of water, per the Synthroid prescribing information¹. Separate it from calcium, iron, antacids, PPIs, and bile acid sequestrants by at least 4 hours. Clara flags the specific items on your chart that need separating.

How long until it works?

Symptoms typically start to improve in 2 to 3 weeks. The Synthroid label directs that steady state after a dose change is reached in approximately 4 to 6 weeks, with repeat TSH drawn accordingly¹. Clara orders the follow-up panel on that clock, not at your next annual.

What if my TSH is in range but I still feel off?

TSH in range is not the same as well-treated. Clara reads Free T3, reverse T3, ferritin, vitamin D, B12, and your symptom pattern before concluding the dose is right. Sometimes the answer is a different levothyroxine brand, a switch to a combination T4 and T3 approach, or investigation of a separate cause (iron deficiency, perimenopause, sleep apnea).

Is Clara a real medical practice?

Yes. Clara operates through affiliated professional corporations licensed in all 50 states. Diagnoses, prescriptions, and lab orders are reviewed and signed off by licensed physicians. The AI handles intake, continuous monitoring, and follow-up; the clinical sign-off happens at the end.

Can I use Clara for more than thyroid?

Yes. One membership covers full primary care — hypothyroidism, blood pressure, cholesterol, diabetes, menopause, mental health, sick-day issues, and longevity work. Most levothyroxine patients have at least one other condition that benefits from the same chart-level reading.

Is my data private?

Clara is HIPAA compliant. Your records are used to personalize your care. They're not sold, and they're not used to train public AI models.

A levothyroxine dose sized to your weight, your labs, and every drug that interacts with it.