Omeprazole · Proton pump inhibitor

Care that knows when omeprazole is working, and when it's time to step down.

Omeprazole is the default first-line for acid reflux, and most patients stay on it longer than guidelines suggest. Clara reads every refill and past endoscopy, flagging when to reassess.

Get started How it works

I've been on omeprazole 20 mg for 14 months. Is it time to try stopping?

Clara

You've been on omeprazole 20 mg since February, and your magnesium has drifted to 1.7. I'd order a B-12 and repeat magnesium, then a 4-week taper to 10 mg with famotidine PRN. Sending to our physician.

Let's do it. What should I watch for during the taper?

How it works

Omeprazole decisions made from your reflux history, not from a refill form.

Connect your chart

Clara auto-syncs records from 150,000+ doctors' offices, hospitals, clinics, labs, and pharmacies. Every past PPI fill, every endoscopy report, every CMP pools into one running view. Free.

Clara reads the full PPI timeline

How long you've been on a PPI, which one, what dose, whether an endoscopy was ever done, alarm symptoms like weight loss or dysphagia, magnesium and B-12 trends, drug interactions (clopidogrel, methotrexate, rilpivirine). Clara drafts the next step and a licensed physician signs off.

Refills, tapers, and step-downs, 24/7

Need a refill at 11pm on a Sunday? Asking whether it's time to taper? Clara reasons from your chart in seconds and drafts the plan. Dose changes and new scripts are sent for sign-off before they're called into your pharmacy.

How Clara uses omeprazole

Starting doses, tapers, alternatives, and long-term monitoring.

Rx · First-line GERD

Omeprazole 20 mg daily

Standard adult starting dose for GERD, taken once daily 30 to 60 minutes before the first meal. The FDA label specifies 20 mg daily for 4 to 8 weeks for GERD and erosive esophagitis¹.

4–8 wk

Standard treatment duration¹

Rx · Step-down

Taper to lowest effective dose

After healing, the goal is the lowest dose that controls symptoms, or transition to an H2 blocker or PRN antacids. Clara drafts a structured 4-week taper personalized to your refill history, not a generic template.

Taper

Personalized from your PPI timeline

Rx · H2 alternative

Famotidine 20–40 mg

H2 blocker, useful as a step-down from daily PPI or for PRN symptom breakthrough. Onset is faster than omeprazole but the effect is shorter. Often paired with a PPI taper rather than used alone for erosive disease.

PRN

Breakthrough and step-down

Rx · H. pylori

Triple therapy (10 days)

Omeprazole 20 mg twice daily plus clarithromycin 500 mg twice daily plus amoxicillin 1 g twice daily for 10 days is the label-supported regimen for H. pylori-associated ulcer disease¹. Clara orders the stool antigen or breath test first where appropriate.

10 days

Label regimen¹

Monitoring · Labs

B-12 and magnesium

Long-term PPI use can lower vitamin B-12 and magnesium. Clara drafts a B-12 level and a basic metabolic panel for patients on a PPI beyond a year, and flags drift early. Ad-hoc lab orders at Labcorp or Quest may be covered by your insurance.

Annual

While on long-term PPI

Supportive · Lifestyle

Weight, triggers, bed elevation

Weight loss, avoiding late meals, head-of-bed elevation, and cutting common triggers (alcohol, late caffeine, large high-fat meals) each have independent effects on reflux. Clara layers these against wearable sleep data and your reflux diary.

Tracked

Integrated with your chart

Why Clara

Omeprazole is cheap. Staying on it the right length of time is what's hard.

	Clara	Teladoc	CVS MinuteClinic	Your doctor
24/7 AI clinical chat with full-chart reasoning	✓ Unlimited	Per-visit only	Per-visit only	✗
Reads your full PPI timeline before prescribing	✓ Automatic	Rotating provider, intake form only	Per-visit records portal	As chart allows
Cost to start	Free (connect records + chat)	Per-visit fee (varies by plan)	$107–$164 cash-pay visit	$150+ copay
Paid plans	$25/mo membership, HSA/FSA eligible	No membership, per-visit billing	No membership, per-visit billing	Per-visit copay
Prescription fills	FDA-approved generic, may be covered by your insurance	Sent to your pharmacy	Sent to your pharmacy	Sent to your pharmacy
Long-term monitoring (B-12, magnesium)	✓ Drafted automatically	Not tracked across visits	Not tracked across visits	Copay applies
Step-down and taper plans	✓ Structured from your refill history	Refill-focused	Refill-focused	At office visit only
Full primary care in one membership	✓	Varies by plan	Single-visit care	✓

The AI difference

Most PPI prescriptions live longer than they should. That's an AI problem.

Can your old doctor read every omeprazole fill going back four years, every endoscopy report, every magnesium and B-12 level, and the note where a prior provider wrote "reassess in 8 weeks" in a 15-minute slot? Clara can, every time you chat.

Refill history, not refill forms

A one-off telehealth refill sees a patient intake form. Clara sees 14 months of omeprazole fills, the endoscopy that never happened, and the original reason the PPI was started. That's the difference between a refill and a plan.

Interaction matrix in seconds

Omeprazole meaningfully interacts with clopidogrel, methotrexate, rilpivirine, and several HIV regimens, and it alters the pH-dependent absorption of multiple drugs. Clara runs the matrix against your full med list before it drafts. A 15-minute visit cannot.

Step-down on a clock

Most long-term PPI use is never reassessed. Clara watches the calendar against guideline cadence and drafts a taper when symptoms are controlled. Your doctor does this at the annual visit, at best.

Common questions

Omeprazole questions patients ask.

How is Clara different from a one-off telehealth refill?

A refill visit on Teladoc or CVS MinuteClinic is a transaction: one visit with a rotating provider, one script, done. Clara is continuous. Your full PPI fill history, endoscopy reports, magnesium and B-12 values, and every drug interaction, Clara reads all of it on every interaction. If it's time to taper, Clara drafts the plan in days, not at the next annual visit. Can your regular doctor read all of that in 15 minutes? Clara can, every time you message.

How long should I stay on omeprazole?

The FDA label supports 4 to 8 weeks of omeprazole 20 mg daily for GERD and erosive esophagitis¹. Many patients need ongoing maintenance for recurrent symptoms or for conditions like Barrett's esophagus, but long-term use should be on the lowest effective dose and periodically reassessed. Clara reads your refill history and flags when it's time to try a step-down.

Can I just stop it, or do I need to taper?

Abrupt discontinuation after long-term PPI use often causes rebound acid hypersecretion and a few weeks of worsened heartburn. A structured step-down is usually easier: typically a 2 to 4 week taper to every-other-day, a switch to an H2 blocker like famotidine, and PRN antacids for breakthrough. Clara builds the taper from your actual dose and duration, not a generic template.

What are the long-term risks of PPIs?

Long-term PPI use is associated with low vitamin B-12, low magnesium, increased risk of C. difficile and community-acquired pneumonia, and in some cohorts with kidney disease and fracture risk. The FDA label includes warnings around hypomagnesemia, B-12 deficiency with prolonged use, and acute interstitial nephritis¹. Clara drafts annual labs for anyone on a PPI beyond a year and flags drift before it becomes a problem.

Does omeprazole interact with my other medications?

It can. Notable interactions include reduced effect of clopidogrel (antiplatelet), increased methotrexate levels, reduced absorption of rilpivirine and some HIV therapies, and variable effects on the absorption of pH-sensitive drugs¹. Clara runs the full interaction matrix against your medication list before drafting an omeprazole prescription or renewal.

Is Clara a real medical practice?

Yes. Clara is licensed in all 50 states and operates through affiliated professional corporations. A licensed physician reviews and signs off on every diagnosis, prescription, and lab order Clara's AI drafts. Clara's AI runs intake, monitoring, and follow-up. See AI primary care for the broader model.

What does Clara cost, and can I use insurance?

Connecting records and chatting with Clara is free. Paid plans start at $25/month for medical advice, prescriptions, and lab orders. All plans are HSA/FSA eligible. Clara's membership itself is cash-pay and is not billed through insurance. Generic omeprazole is inexpensive (commonly $4 to $15 cash-pay for a 30-day supply with a GoodRx coupon), and prescriptions Clara writes go to your pharmacy and may be covered by your insurance. Ad-hoc lab orders (B-12, magnesium, H. pylori testing) at Labcorp or Quest may be covered by your insurance.

Can I use Clara for other health issues too?

Yes. One membership covers full primary care. Patients on a PPI often also track acid reflux and GERD triggers, hypertension, or biomarker panels that include B-12 and magnesium; Clara connects the dots across all of them. Wearable integration comes with the Standard plan.